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Medicine Subject Guides: Synthesizing data

Synthesizing data

Synthesizing and analyzing data in a systematic review involves combining the results of individual studies to generate a comprehensive summary of the evidence. This process aims to identify patterns, trends, and relationships across studies, allowing for a more robust understanding of the research question or topic under investigation.

Qualitative Synthesis

Qualitative synthesis is an essential component of all systematic reviews, including those with a primary focus on quantitative data. It involves a narrative and textual approach to summarize, analyze, and evaluate the body of evidence included in the review.

Quantitative Synthesis (Meta-analysis)

In cases where the included studies are qualitative in nature, a qualitative synthesis can be conducted. This involves analyzing and synthesizing the qualitative data, such as themes, concepts, or theories, from the individual studies. 
 

Synthesis Methods

  1. Narrative synthesis:
  2. Descriptive and qualitative summary of findings without statistical pooling of data.

  3. Meta-analysis:
  4. Quantitative method that combines results from multiple studies to provide a pooled estimate of the treatment effect.

  5. Meta-ethnography:
  6. Qualitative synthesis method for comparing and interpreting findings from qualitative studies.

  7. Thematic synthesis:
  8. Qualitative method that identifies and synthesizes key themes or concepts across studies.

  9. Mixed-methods synthesis:
  10. Integration and analysis of both quantitative and qualitative data in systematic reviews.

Tools for synthesizing data

A forest plot is a useful way to represent the collected data accurately. It combines results from various clinical trials, displaying point estimates from different studies regarding a specific condition or treatment. The plot consists of a graphical representation, usually accompanied by a table. The graph illustrates the mean value for each trial along with confidence intervals represented by horizontal bars. Each mean is plotted relative to the vertical line of no difference.

Useful online tools for forest plot:

Forest plot generator 

MedCalc Software 

SRplot

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